Latest generation IgE Component allergy test - CAAM FABER

The first generation of blood allergy test was invented in the 1970s. It involves binding allergenic extracts to a solid phase and then incubating this with the patient’s serum, then to measure with labeled radioactive IgE. This radioallergosorbent test (RAST) involves dangerous radioactive materials and could only be performed in specially equipped laboratories.

The second generation tests involve measuring the degree of colour change or the strength of the fluorescence to determine the quantity of bound anti-IgE antibodies.

Recent developments in allergy blood tests include the use of molecular allergens. Since a crude allergen extract contains many different proteins and only a few can cause allergic reaction, binding to irrelevant proteins often result in false positive result. Therefore, the latest generation has taken out those non-allergenic proteins, improving the overall test accuracy. Another recent development is the multiplex assay. The previous tests required a lot of blood samples and can easily bind with non-specific IgE, leading to false positive results. However, with the use of multiplex assay, the amount of allergens needed can be greatly reduced, thus lowering the cost of the test. It also allows more allergens to be tested with a given amount of blood sample. Faber allergy test employs nanotechnology and the latest generation multiplex assay, such that it can accurately measure total IgE level up to 45,000 IU/ml in blood serum

Why are eczema patients more fitted for CAAM Faber allergy test?

Eczema patients are more suitable for blood tests because the pre-existing eczema skin condition might affect and reduce the accuracy of a skin prick test.

For food allergy, allergens in food bind with IgE antibodies in blood, triggering the release of histamine by mast cells, causing allergic reactions. Taking peanut as an example, peanut has 17 different allergen molecules. Among which allergen molecules with a greater chance of causing severe allergic reactions include: Ara h 2 and Ara h 6. Other molecule such as Ara h 8 has a low risk triggering an allergic reaction. Therefore, allergen molecular test is very helpful for risk assessment of allergic reactions in patients with eczema.

In fact, there are over 600 allergens that can cause allergic reactions, of which around 300 are molds that can only be found in specific countries and regions. The latest IgE allergy test Faber can detect more than 200 clinically identified allergens, and it is already comprehensive and sufficient enough for eczema patients.

Why is the blood sample of the 3rd and Latest Generation IgE Allergy Test sent to Italy for testing?

Faber Education Video

Academic Literature

The most recent academic literature indicates “Molecular Allergens” is an accurate method in food allergy tests.

European Academy of Allergy and Clinical Immunology (EAACI) Annual Conference Publication release (October 2016)

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Molecular Allergen-Specific IgE Assay Allergy Test Publication Release (2015)

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