Cancer genetic test (70 Kinds)

Hereditary breast and ovarian cancer syndromes caused by BRCA1 and BRCA2 gene mutations are common in family history or early-onset disease diagnosis.

Hereditary breast cancer and ovarian cancer syndrome are the most common causes of ovarian cancer.

Lynch Syndrome is the most common cause of hereditary uterine cancer.

Hereditary colorectal cancer syndrome is usually divided into two types: Lynch syndrome and polyposis syndrome. Lynch syndrome is also known as hereditary non-polyposis colon cancer (HNPCC). Caused by virulent mutations in EPCAM, MLH1, MSH2, MSH6 and PMS2, it is the most common genetic cause of colorectal cancer. Polyposis syndrome is characterized by the development of many precancerous polyps that may become malignant.

One cause of hereditary gastric cancer is the virulence mutation of CDH1, which can lead to hereditary diffuse gastric cancer syndrome. Gastrointestinal stromal tumors are characterized by sarcomas, which are rare tumors of the gastrointestinal tract, accounting for 1%-3% of all gastric cancers.

There are two main types of pancreatic cancer: exocrine pancreatic cancer (pancreatic adenocarcinoma) accounts for 95% of pancreatic tumors; and pancreatic neuroendocrine tumors. Hereditary pancreatic cancer can be caused by BRCA2 and CDKN2A, as well as several other genes.

Hereditary cancers of the kidney and urinary tract are usually characterized by earlier disease onset or bilateral tumors. Hereditary urinary tract cancer may also be a syndrome.

Around 5-10% of prostate cancer cases are inherited.

Although the number of individuals with a genetic risk of melanoma is not yet known, it is believed that the number is low. About 1%–2% of melanoma patients have two or more affected relatives.

Medullary thyroid carcinoma (MTC) is a relatively rare malignant tumor of the thyroid that is closely related to hereditary cancer syndromes. The familial type of MTC accounts for 20%-25% of cases and is usually part of type 2 multiple endocrine tumors (MEN2), including MEN2A and MEN2B subtypes, or familial MTC (FMTC) syndrome.